Research Highlight

Herbs from Amazon, Andes for osteoarthritis

Subhra Priyadarshini

doi:10.1038/nindia.2007.29 Published online 1 November 2007

A new polyherbal dietary supplement, Reparagen, has been found to be safe and effectivene in treating moderate osteoarthritis. Studying its effects on patients in Mumbai, researchers have reported that its components – tea derived from an Amazonian rainforest vine and another Andean vegetable – had this unique combination that may promote joint repair1.

Mark Miller

One component of Reparagen is a tea derived from an Amazonian rainforest vine (Uncaria guianensis), and is a potent inhibitor of the protein NF-kB, that drives the genes causing inflammation and joint destruction. The other component is derived from an Andean vegetable, Lepidium meyenii, and this energizes the production of IGF-1 in human cartilage. IGF-1 is the critical factor in promoting cartilage repair and growth.

Current allopathic medical approaches to osteoarthritis do not stop the disease process, and joint destruction continues unabated. "Hence, it is critical to find new approaches," says researcher Mark Miller.

The study concluded that Reparagen is a remarkably safe and effective natural product approach to managing osteoarthritis and could be an important step in defining approaches that may actually repair damaged joints.

The authors of this work are from: Vedic Lifesciences, Pvt. Ltd., Mumbai, India; A-1, Om Kamal Bldg, Mumbai; Diamond Hospital, Mumbai; Naik Hospital, Pune, India; Yogesh Hospital, Pune; Department of Health Services Studies, Tata Institute of Social Sciences, Mumbai; Albany Medical College, Albany, USA.


  1. Miller, Mark J. S. et al. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Complementary and Alternative Medicine doi:10.1186/1472-6882-7-34 (2007).