Research Highlight

Electrode signals heart risk

doi:10.1038/nindia.2010.55 Published online 28 April 2010

Researchers have devised a special type of electrode that can detect homocysteine (HCY), an amino acid in blood that signals higher risk of coronary heart disease.

To design a detector, the researchers coated glassy carbon electrode (GCE) with electropolymerised film of 2-amino-1,3,4-thiadiazole (ATD).

The film of ATD formed a spherical structure with a thickness of 25 nm. The coated electrodes selectively detected HCY even in the presence of ascorbic acid in human blood samples. The bare electrode failed to react with HCY.

The modified electrode also detected HCY in the presence of glucose and urea.


  1. Kalimuthu, P. et al. Selective determination of homocysteine at physiological pH using nanostructured film of aminothiadiazole modified electrode. Bioelectrochemistry doi:  10.1016/j.bioelechem.2010.02.006 (2010)