Research Highlight

Convulsion, diabetes shield

doi:10.1038/nindia.2010.63 Published online 20 May 2010

A type of organic compounds called benzimidazole derivatives have been found promising in the treatment of diabetes and convulsion.

Researchers probed the efficacy of these compounds in animals. They conducted 'maximal electroshock seizure' (MES) tests and also screened the compounds for any antidiabetic activity using 'oral glucose tolerance test' (OGTT).

Both tests revealed the efficacy of the compounds in countering diabetes and seizure.

In DNA cleavage studies, one of the compounds cleaved DNA completely leaving no trace behind.

The findings of the research are significant as they may yield new drugs to combat convulsion and diabetes.


  1. Ramya, S. V. et al. Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies. Eur. J. Med. Chem. 45, 1753-1759 (2010) | Article | PubMed |